Milestone Games
| First Game | 1889 at Rochester (0-36) |
| First Victory | 1890 vs. Syracuse Athletic Association (14-0) |
| First Loss | 1889 at Rochester (0-36) |
| Last Shutout | Sep. 10, 2005 vs. Buffalo (31-0) |
| Last time shutout by opponent | Sep. 8, 2007 at Iowa (0-35) |
| First Undefeated Season | 1959 (11-0-0) |
| Last Undedeated Season | 1987 (11-0-1) |
| First Bowl Game | Jan. 1, 1952 (Orange Bowl vs. Alabama (6-61), Miami, Fl.) |
| Last Bowl Game | Dec. 21, 2004 (Champs Sports Bowl vs. Georgia Tech (14-51), Orlando, Fl.) |
| First TV Game | CBS - Jan. 1, 1952 (Orange Bowl vs. Alabama (6-61), Miami, Fl.) |
| Last TV Game | ESPN - Dec. 30, 2010 (vs. Kansas State (36-34), New York City, NY), |
| 1st Game | 1889 vs. Rochester (0-36) |
| 50th Game | 1894 vs. Cornell Reserves (22-0) |
| 100th Game | 1899 vs. N.Y.U. (10-5) |
| 200th Game | 1910 vs. St. Bonaventure (0-0) |
| 300th Game | 1920 vs. Pittsburgh (7-7) |
| 400th Game | 1930 at Columbia (19-7) |
| 500th Game | 1944 vs. Cornell (6-39) |
| 600th Game | 1955 at Holy Cross (49-9) |
|
700th Game |
1965 vs. Pittsburgh (51-13) at Shea Stadium, Flushing, NY |
| 800th Game | 1975 vs. Iowa (10-7) |
| 900th Game | 1984 at Northwestern (13-12) |
| 1000th Game | 1992 at Temple (38-7) at Veterans Stadium, Philadelphia, PA |
| 1100th Game | 2001 vs. Georgia Tech (7-13) at Meadowlands, East Rutherford, NJ |
| 1200th Game | 2009 vs. West Virginia (13-34) |
| 1220th Game | 2010 vs. Kansas State (36-34) |
| 1st Win | 1890 vs. Syracuse Athletic Association (14-0) |
| 50th Win | 1900 vs. Cortland Normal (35-0) |
| 100th Win | 1907 vs. Hamilton (22-0) |
| 150th Win | 1917 vs. Bucknell (42-0) |
| 200th Win | 1924 vs. Boston College (10-0) |
| 250th Win | 1932 vs. Ogelthorpe (27-6) |
| 300th Win | 1946 vs. Temple (28-7) |
| 350th Win | 1957 at Nebraska (26-9) |
|
400th Win |
1964 vs. Kansas (38-6) |
| 450th Win | 1971 vs. West Virginia (28-24) |
| 500th Win | 1983 at Navy (14-7) |
| 550th Win | 1990 vs. Temple (19-9) |
| 600th Win | 1996 vs. Pittsburgh (55-7) |
| 650th Win | 2002 at Central Florida (38-35) |
| 685th Win | 2010 vs. Kansas State (36-34) |
| 1st Loss | 1889 at Rochester (0-36) |
| 50th Loss | 1900 at Princeton (0-43) |
| 100th Loss | 1916 vs. Dartmouth (10-15) at Springfield, MA |
| 150th Loss | 1937 vs. Colgate (0-7) |
| 200th Loss | 1950 at Temple (6-7) |
| 250th Loss | 1966 vs. Tennessee (12-18) |
| 300th Loss | 1976 vs. Bowling Green (7-22) |
| 350th Loss | 1983 vs. Penn State (6-17) |
| 400th Loss | 1998 vs. Tennessee (33-34) |
| 450th Loss | 2006 at West Virginia (17-41) |
| 486th Loss | 2007 vs. Boston College (7-16) |
